for Amikacin

Version: 0.95.5 beta / Built 20170531

TDMx has been created for personal use only. The use of any result generated by TDMx is in any case the sole risk and responsibility of the TDMx user. Therapeutic decision should not solely rely on TDMx as information provided by TDMx does not replace clinical judgement. Although TDMx has been validated carefully, there is no guarantee for the accuracy of the provided results.

When using TDMx, you automatically agree with this disclaimer and the legal notices!

All Rights Reserved, 2017

Dr. Sebastian G. Wicha

c/o University of Hamburg, Germany

Information to users:
This is a beta version! You can improve TDMx by reporting any bug/issue you observed! Just email us!
Population PK model (critically ill): Romano et al. Clin Drug Invest, 1998: 435-44

Powered by RStudio(TM)

R Core Team (2014). R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria.
Dose [mg] | Infusion dur. [h]

Serum creatinine [mg/dL]

Measured amikacin [mg/L]

Time [dd/mm/yyyy/hh:mm]

Dose [mg]

Infusion duration [h]

cGentamicin [mg/L]


Time [dd/mm/yyyy/hh:mm]

Cmax/MIC [-]

Cmin [mg/L]

Infusion duration [h]

Probabilistic dosing scenarios (no drug measurements used/needed!)



Time [dd/mm/yyyy/hh:mm]

Cmax/MIC [-]

Cmin [mg/L]

Infusion duration [h]

Prediction of next dose based on individual patient (using Bayesian estimates)

PK model

Warning: Modification of PK model recommended for research purposes only!

Available covariates:

SEX_i: Sex (male=0, female=1)

WT_i: Weight (kg)

HT_i: Height (cm)

AGE_i: Age (yrs.)

CLCRCG_i_t: Creatinine Clearance (Cockcroft Gault 1976) (ml/min) (time-dependent)

CLCRJ_i_t: Creatinine Clearance (Jelliffe 1973) (ml/min) (time-dependent)

SCR_i_t: Serum creatinine (mg/dL) (time-dependent)

TRAUMA_i: Trauma (yes=1, no=0)

SEPSIS_i: Sepsis (yes=1, no=0)

PK/Covariate model:
Interindividual variability of PK parameters:
Residual unexplained variability (RUV):