TDMx NeoGent

Gentamicin in neonates

Version: 0.95.5 beta / Built 20170531

Disclaimer:

TDMx has been created for personal use only. The use of any result generated by TDMx is in any case the sole risk and responsibility of the TDMx user. Therapeutic decision should not solely rely on TDMx as information provided by TDMx does not replace clinical judgement. Although TDMx has been validated carefully, there is no guarantee for the accuracy of the provided results.

When using TDMx, you automatically agree with this disclaimer and the legal notices!

Dr. Sebastian G. Wicha

University of Hamburg, Hamburg, Germany

Dr. Eva Germovsek

c/o Uppsala University, Sweden

Dr. Joseph Standing

c/o University College London, UK

Information to users:

This is a beta version! You can improve TDMx by reporting any bug/issue you observed! Just email us!

References

Population PK model (neonates): Germovsek et al. Antimicrob Agents Chemother, 2016: 4869-77

R Core Team (2014). R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria.

Demographics

Date/time of birth Gestational age at birth [weeks]

Weight [kg]

Dose [mg] | Infusion dur. [h]

Dosing interval (for next dose) [h]

Laboratory

Serum creatinine [umol/L]

MIC [mg/L]

Measured gentamicin [mg/L]

Time [dd/mm/yyyy/hh:mm]

Dose [mg]

Infusion duration [h]

cGentamicin [mg/L]

Probabilistic dosing scenarios (no drug measurements used/needed!)

Prediction of next dose based on individual patient (using Bayesian estimates)

Modification of population PK model not possible!